2
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10866 | Cot inhibitor-2 | TNF , MAPK | |
Cot inhibitor-2 is a cot (Tpl2/MAP3K8) inhibitor (IC50: 1.6 nM) with potency, selectivity and oral activity. cot inhibitor-2 inhibits LPS-stimulated TNF-α production in human whole blood with an IC50 of 0.3 μM. | |||
T10865L | Cot inhibitor-1 hydrochloride | Cot inhibitor-1 hydrochloride(915365-57-0 Free base) | TNF , MAPK |
Cot inhibitor-1 hydrochloride is an inhibitor of tumor progression loci-2 kinase (IC50 = 28 nM) and inhibits the production of TNF-α in human whole blood (IC50 = 5.7 nM). |